ANTIBIOTIC SUSCEPTIBILITY OF ACINETOBACTER BAUMANNII STRAINS ISOLATED IN SOME VIETNAMESE HOSPITALS IN THE PERIOD 2017-2019
Keywords:
Acinetobacter baumannii, MIC, antibiotic resistance, carbapenem, colistinAbstract
The study was to determine the Minimum Inhibitory Concentration (MIC) of 157 Acinetobacter baumannii strains isolated on inpatients from 6 hospitals in Vietnam including: Huu Nghi Hospital , Hospital 108, Thanh Nhan Hospital, Saint Paul Hospital, Hue Central Hospital, Can Tho Provincial General Hospital in the period 2017-2019. MIC results showed that A. baumannii was resistant to ≥ 77% to 8/9 tested antibiotics; 91% of A. baumannii were resistant to both carbapenem antibiotics, meropenem and imipenem, with MIC50 of 32 - 64 µg/ml and MIC90 ≥ 64 µg/ml. The lowest resistance rate was colistin (34,3%) and the MIC range of colistin ranged from < 0,25 - ≥ 4 µg/ml; MIC50 = 1 µg/ml, MIC90 = 4 µg/ml. Research results are the basis for clinical pharmacists and treating doctors to calculate an effective and safe treatment dose that is appropriate for the patient.
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