CHEMICAL COMPOSITION AND ANTI-INFLAMMATORY ACTIVITITES OF MORINDA OFFICINALIS COLLECTED IN THAI NGUYEN
Keywords:Morinda umbellata; anti-inflammatory; Thai Nguyen
From the stems of Morinda umbellata trees, using HPLC and according to the IV Pharmacopoeia, the content of major chemical compounds was determined to be tannin (2.6%), saponin (1.7%), phytosterol (26.3%), flavonoid (2.1%), and alkaloid (2.9%). The in vitro anti-inflammatory activity was tested through the inhibition of NO production on the macrophages of Morinda umbellata (RAW264.7). The results showed that the high-concentration extract (MU) exhibited good anti-inflammatory activity with an IC50 value of 36.2 µg/ml and high cell survival rate. The ethyl acetate fraction (MUE) demonstrated the best anti-inflammatory activity, with an IC50 value of 18.1 µg/ml and higher cell survival rate compared to the positive control [Cardamonin], which had an IC50 value of 10.5 µM. These promising findings, along with further studies, may contribute to unlocking the potential of Morinda umbellata for functional food and pharmaceutical applications, thus utilizing this plant species effectively.
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