Effects of Hormone Growth and Insulin Growth Factor 1 on Longitudinal Bone Growth
DOI:
https://doi.org/10.51453/2354-1431/2017/129Keywords:
Hormone Growth; Insulin Growth Factor 1; bone growth; osteoblasts.Abstract
Growth hormone (GH) and Insulin Growth Factor 1 (IGF-I) plays an important role in the development of body height through the effects on bone. Many studies in humans and animals shows that GH stimulates longitudinal bone growth directly by stimulating prechondrocytes in the
growth plate followed by a clonal expansion and IGF-I stimulates cells in the later stages by reducing the cell cycle time. In addition, GH and IGF-I also promote additional effects or interact with each other when they are brought into the body together.
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