THE IN VITRO CYTOTOXICITY ACTIVITIES OF THE EXTRACTS FROM CALLICARPA MACROPHYLLA VAHL IN THAI NGUYEN PROVINCE
DOI:
https://doi.org/10.51453/2354-1431/2021/553Keywords:
Callicarpa macrophylla Vahl, Callicarpa, Lu-1, Hep-G2 and MCF-7.Abstract
Callicarpa macrophylla Vahl. has widely been used in traditional medicine for the treatment such as gastrointestinal hemorrhage, coughing up blood, vomiting blood, nosebleeds, swollen and painful fall, rheumatism, bone pain, etc. The crude extract of the stem, leaves and fruits of Callicarpa macrophylla Vahl have exhibited demonstrated cytotoxicity against three human cancer cell lines (Lu-1, Hep-G2 và MCF-7) was tested by SRB assay with CS (%) values ranging from 30,23 ± 1,5 to 90,22 ± 0,15%. Inside, The methanol extract of the leaves of Callicarpa macrophylla Vahl have showed relatively potent cytotoxicity with CS (%) values ranging from 30,23 ± 1,5 to 47,84 ± 2,1%. The n-hexane fraction (L.CM.H) of the leaves of Callicarpa macrophylla Vahl have exhibited potent against three human cancer cell lines (Lu-1, Hep-G2 và MCF-7) than ethyl acetate fraction (L.CM.E) and methanol fraction (L.CM.M) with CS (%) values ranging from 12,49 ± 1,4 to 20,18 ± 0,8%.
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