EVALUATE THE ACUTE TOXICITY AND THE SEDATIVE ACTIVITY OF AN THAN - TN TABLETS IN EXPERIMENTAL ANIMALS

Authors

  • Tran Thanh Binh Thai Nguyen Traditional Medicine Hospital, Vietnam
  • Truong Thi Thu Huong Thai Nguyen Traditional Medicine Hospital, Vietnam
  • Hoang Cong Huy Thai Nguyen Traditional Medicine Hospital, Vietnam
  • Pham Thi Van Anh Hanoi Medical University, Vietnam
  • Luu Hong Son Thai Nguyen University of Agriculture and Forestry, Vietnam

DOI:

https://doi.org/10.51453/2354-1431/2021/597

Keywords:

An than - TN tablets, acute toxicity, advanced cross model, activity cage model, Rotarod test.

Abstract

To evaluate the acute toxicity of An than - TN tablets made in Thai Nguyen traditional medicine hospital in experimental animals to the guidelines of the World Health Organization. The sedative effect was examined by advanced cross model, activity cage model, and the able to maintain of Swiss mice on the rotating rod of Rotarod test was assessed. The results showed that An than - TN from a dose of 21.2625g/kg to the highest dose of 35.4375g/kg did not show acute toxicity in mice. An Than -TN tablets at the dose of 1.44 tablets/kg/day and 4.32 tablets/kg/day did show the sedative activity on activity cage model, the advance cross and shortened the maintaining time of Swiss mice on Rotarod. Therefore, An than - TN tablet expressed no acute toxicity and had the effect of treating sleep disorders in experimental animals.

Downloads

Download data is not yet available.

References

[1] National Institute of Medicinal Materials. (2006). Research Methods on Pharmacological Effects of Herbal Medicine. Science and Technics Publishing House, Ha Noi, Vietnam

[2] Gerhard, V. H. (2016). Drug discovery and evaluation Pharmacological assays, Springer.

[3] Robert, M. J. D. (2013). Measuring Motor Coordination in Mice. Journal of Visualized Experiments, 75: 2609.

[4] World Health Organization. (2013). Working group on the safety and efficacy of herbal medicine. Report of regional office for the western pacific of the World Health Organization.

[5] Mill, J., Galsworthy, M. J., Paya-Cano, J. L. (2002). Home-cage activity in heterogeneous stock (HS) mice as a model of baseline activity. Genes, Brain and Behavior, 1(3): 166-173.

[6] Olayiwola, G., Ukponmwan, O., Olawode, D. (2013). Sedative and anxiolytic effects of the extracts of the leaves of Stachytarpheta cayennensis in mice. African Journal of of Traditional, Complementary and Alternative medicines, 10(6):568-579.

[7] http://thankinh.edu.vn/chi_tiet/254/Tong-Quan-Dieu-Tri-Mat-Ngu.html

Published

2021-09-06

How to Cite

Trần Thanh, B., Trương Thị, T. H., Hoàng Công, H., Phạm Thị, V. A., & Lưu Hồng, S. (2021). EVALUATE THE ACUTE TOXICITY AND THE SEDATIVE ACTIVITY OF AN THAN - TN TABLETS IN EXPERIMENTAL ANIMALS. SCIENTIFIC JOURNAL OF TAN TRAO UNIVERSITY, 7(22). https://doi.org/10.51453/2354-1431/2021/597

Issue

Section

Natural Science and Technology

Most read articles by the same author(s)

1 2 > >>