STUDY ON PREPARATION BACTERIAL CELLULOSE NANOFIBERS COATED NANOLIPOSOMES CONTAINING DOXORUBICIN USING FOR ORAL ADMINISTRATION
DOI:
https://doi.org/10.51453/2354-1431/2024/1116Keywords:
Bacterial cellulose nanofibers, doxorubicin, nanoliposomes, oral administration, sustained release.Abstract
Doxorubicin (DOX) is a potential anti-cancer agent but has limited clinical applications due to serious side effects caused by parenteral administration and low oral bioavailability. Preparation of nanoliposomes (LIP) is considered an effective solution to increase the oral bioavailability of DOX. This study aims to prepare the LIP-DOX coated with bacterial cellulose nanofibers (NanoBCF) for oral administration. The LIP-DOX or NanoBCF-LIP-DOX was successfully prepared using the hydration method. The obtained LIP-DOX or NanoBCF-LIP-DOX have nano-sized size (< 200 nm), with uniform distribution (PDI < 0.25) and high encapsultion efficiency (> 80%). The release of DOX from LIP-DOX, or from NanoBCF-LIP-DOX lasts up to 12 hours. DOX release from NanoBCF-LIP-DOX was slower than from LIP-DOX. The release of DOX from LIP-DOX or from NanoBCF-LIP-DOX follows a diffusion mechanism and follows the Higuchi model (in NanoBCF-LIP-DOX) and the Korsmeyer-Peppas model (in LIP-DOX). The results demonstrated the successful preparation of the NanoBCF-LIP-DOX system to create a potential sustained-release DOX delivery system for oral administration.
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