EVALUATION OF THE CURCUMIN RELEASE OF CHITOSAN COATED NANOLIPOSOMES CONTAINING CURCUMIN USING FOR ORAL ADMINISTRATION
Keywords:Chitosan, curcumin, nanoliposomes, oral administration, release
Curcumin (Cur) has the potential to aid in the treatment of many diseases, but limited in efficacy because of its very low bioavailability. Cur is poorly absorbed, metabolized quickly and is excluded from the circulatory system. Preparation of nanoliposomes containing Cur (Lip-Cur) is a solution to improve oral bioavailability. Objective: This study aimed to prepare and evaluate the Cur release of chitosan coated nanoliposomes containing Cur (Chi-Lip-Cur) for oral adminstration. Methods: Nanosystems (Lip-Cur or Chi-Lip-Cur) were successfully prepared by thin film hydration method. Results: Cur release rate of Lip-Cur or Chi-Lip-Cur is fast in the first 30 minutes and later slow. Cur release from Lip-Cur last up to 6 hours, while Chi-Lip-Cur last up to 12 hours. Cur is released from Chi-Lip-Cur at a slower rate than Lip-Cur. Cur is released from Lip-Cur or Chi-Lip-Cur reached the highest value of pH 6.8 and lowest at pH 2.0. Conclusion: The results suggested that Chi-Lip-Cur has been successfully formulated to create an extended-release Cur delivery system for oral administration.
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